Santschi Valérie, Wuerzner Grégoire, Schneider Marie-Paule, Bugnon Olivier, Burnier Michel
Policlinique Médicale Universitaire, Lausanne, Switzerland.
Eur J Clin Pharmacol. 2007 Dec;63(12):1179-84. doi: 10.1007/s00228-007-0364-7. Epub 2007 Sep 25.
The goal of this study was to evaluate clinically the acceptability of the IDAS II (Intelligent Drug Administration System), a new electronic device that enables drug adherence monitoring.
IDAS II was compared to another electronic monitor, the Medication Event Monitoring System (MEMS) in a randomised two-way cross-over study involving 24 hypertensive patients treated with irbesartan. Patients used each device for 2 months. The main parameter of evaluation was the patients' opinion on both devices. Rates of adherence and blood pressure were also assessed.
Most patients considered both devices to be reliable reminders (IDAS II: 75%;MEMS: 84%, p = ns). Ten patients (42%) preferred the MEMS, while 11 (46%) preferred the IDAS II; three (12%) expressed no preference. Patients found the MEMS device easier to use than the IDAS device (p < 0.001) but appreciated the IDAS blister packs better than the MEMS bulk packaging (p < 0.01). Over the 4-month period, the median "taking adherence" was excellent (99.2%) and comparable with both devices. However, the regularity of drug intake timing was higher with the IDAS II (p < 0.01).
IDAS II, a new electronic device enabling drug adherence monitoring without reconditioning of the drugs appears to be a well-accepted device. Overall, practicability and acceptability of the IDAS II and the MEMS device were similar. Thus, IDAS II could be a useful tool for the management of long-term therapies.
本研究旨在临床评估IDAS II（智能药物管理系统）这一新型电子设备在药物依从性监测方面的可接受性，该设备可实现药物依从性监测。
在一项随机双向交叉研究中，将IDAS II与另一种电子监测器——药物事件监测系统（MEMS）进行比较，该研究纳入了24名接受厄贝沙坦治疗的高血压患者。患者使用每种设备2个月。主要评估参数是患者对两种设备的看法。同时还评估了依从率和血压。
大多数患者认为两种设备都是可靠的提醒工具（IDAS II：75%；MEMS：84%，p值无统计学意义）。10名患者（42%）更喜欢MEMS，而11名患者（46%）更喜欢IDAS II；3名患者（12%）表示无偏好。患者发现MEMS设备比IDAS设备更易于使用（p<0.001），但相比MEMS的散装包装，患者更喜欢IDAS的泡罩包装（p<0.01）。在4个月的时间里，“服药依从性”中位数很高（99.2%），两种设备相当。然而，IDAS II的药物摄入时间规律性更高（p<0.01）。
IDAS II是一种无需对药物进行重新包装即可实现药物依从性监测的新型电子设备，似乎是一种广受欢迎的设备。总体而言，IDAS II和MEMS设备的实用性和可接受性相似。因此，IDAS II可能是长期治疗管理的有用工具。
