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G蛋白偶联受体的功能性膜扩散

Functional membrane diffusion of G-protein coupled receptors.

作者信息

Baker Aurélie, Saulière Aude, Dumas Fabrice, Millot Claire, Mazères Serge, Lopez André, Salomé Laurence

机构信息

Institut de Pharmacologie et Biologie Structurale, UMR CNRS-Université Paul Sabatier 5089, 205, route de Narbonne, 31077, Toulouse cedex 09, France.

出版信息

Eur Biophys J. 2007 Nov;36(8):849-60. doi: 10.1007/s00249-007-0214-7. Epub 2007 Sep 26.

DOI:10.1007/s00249-007-0214-7
PMID:17899063
Abstract

G-protein-coupled receptor function involves interactions between the receptor, G-proteins and effectors in the cell plasma membrane. The main biochemical processes have been individually identified but the mechanisms governing the successive protein-protein interactions of this complex multi-molecular machinery have yet to be established. We discuss advances in understanding the functional dynamics of the receptor resulting from diffusion measurements, and in the context of the plasma membrane organization.

摘要

G蛋白偶联受体的功能涉及受体、G蛋白和细胞质膜中的效应器之间的相互作用。主要的生化过程已被逐一确定，但控制这种复杂多分子机制中连续蛋白质-蛋白质相互作用的机制尚未确立。我们将讨论在扩散测量的背景下，以及在质膜组织的背景下，对受体功能动力学理解的进展。

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J Biol Chem. 2007 Nov 30;282(48):35163-8. doi: 10.1074/jbc.M705617200. Epub 2007 Sep 13.
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