各种精子参数与不明原因的反复早期妊娠丢失的关联——哪一个最重要？
Association of various sperm parameters with unexplained repeated early pregnancy loss--which is most important?
作者信息
Bhattacharya Sudhindra Mohan
机构信息
Department of Obstetrics and Gynecology, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata 700026, India.
出版信息
Int Urol Nephrol. 2008;40(2):391-5. doi: 10.1007/s11255-007-9282-y.
OBJECTIVES
To study the relationship of various sperm characteristics with repeated unexplained early pregnancy loss.
BASIC PROCEDURE
Semen samples from husbands of 74 couples with the history of repeated early pregnancy loss were analyzed as per WHO criteria, and DNA integrity was studied in each case by Acridine Orange staining test. Semen samples from 65 husbands of proven fertility were also studied for comparison.
MAIN FINDINGS
No statistically significant differences were noted in the age of the husbands, sperm concentration, total count per ejaculate, and rapid progressive motility of sperms between the two groups. On the other hand, significant differences were found in total motile sperms per ejaculate, percentage of motile sperm and, most importantly, in the DNA integrity value.
CONCLUSION
The sperm DNA-integrity damage is an important paternal factor associated with repeated embryonic or early fetal loss and should be included in the evaluation of these couples.
目的
研究各种精子特征与反复不明原因早期妊娠丢失之间的关系。
基本步骤
按照世界卫生组织标准对74对有反复早期妊娠丢失病史夫妇的丈夫的精液样本进行分析，并通过吖啶橙染色试验研究每例样本的DNA完整性。还对65名经证实有生育能力的丈夫的精液样本进行研究以作比较。
主要发现
两组丈夫的年龄、精子浓度、每次射精的总数以及精子的快速前向运动能力方面未发现统计学上的显著差异。另一方面，在每次射精的总活动精子数、活动精子百分比，以及最重要的是在DNA完整性值方面发现了显著差异。
结论
精子DNA完整性损伤是与反复胚胎或早期胎儿丢失相关的一个重要父方因素，应纳入对这些夫妇的评估中。
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