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一种新型铕掺杂磷灰石/硅灰石多孔磁性生物活性玻璃陶瓷

[A novel europium doped apatite/wollastonite porous magnetic bioactive glass ceramic].

作者信息

Zhang Wangzhi, Zhou Dali, Yang Weizhong, Yin Guangfu, Ou Jun

机构信息

College of Material Science and Engineering, Sichuan University, Chengdu 610064, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Aug;24(4):785-9.

Abstract

A new biocompatible apatite-wollastonite magnetic glass ceramic has been synthesized via sol-gel process. Characteristics of the materials were determined with differential thermal analysis (DTA), X-ray diffraction (XRD), scan electron microscopy (SEM), energy dispersive spectrum (EDS), inductively couple plasma atomic emission spectroscopy (ICP-AES), vibrating sample magnetometer (VSM) and so on. Results showed that the main crystalline phases of the material were hydroxyapatite/fluoroapatite [Ca10(PO4)6(OH, F)), beta-wollastonite[beta-CaSiO3] and calcium europium oxide silicate Ca2Eu8[(SiO4)6O2]. The magnetization of the sample contanining 2% Eu2O3 in weight reached 2.18 emu/g for an applied field of 10 000Oe. Hydroxyapatite layer could form on the surface of the sample while soaking for 14 days in simulated body fluid. Good bioactivity was demonstrated. So it is a potential bone repairing material as well as a hyperthemia treatment material for pateints with cancer.

摘要

通过溶胶-凝胶法合成了一种新型生物相容性磷灰石-硅灰石磁性玻璃陶瓷。采用差示热分析(DTA)、X射线衍射(XRD)、扫描电子显微镜(SEM)、能谱分析(EDS)、电感耦合等离子体原子发射光谱(ICP-AES)、振动样品磁强计(VSM)等对材料的特性进行了测定。结果表明,该材料的主要晶相为羟基磷灰石/氟磷灰石[Ca10(PO4)6(OH,F)]、β-硅灰石[β-CaSiO3]和钙铕氧化物硅酸盐Ca2Eu8[(SiO4)6O2]。对于10000奥斯特的外加磁场,含2%(重量)Eu2O3的样品的磁化强度达到2.18emu/g。样品在模拟体液中浸泡14天时,其表面可形成羟基磷灰石层。证明了其具有良好的生物活性。因此,它是一种潜在的骨修复材料,也是一种用于癌症患者的热疗材料。

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