Caruso C, Candore G, Lio D, Modica M A, Cataldo F, Maltese I, Marino V, Albeggiani A
Istituti di Patologia generale, Università di Palermo, Italia.
Exp Clin Immunogenet. 1991;8(2):85-7.
We studied the role of the immunoglobulin heavy-chain allotypes in the evolution of celiac disease. Particularly the Gm(fb) phenotype was investigated since this phenotype is able to determine the breadth of immune response against alpha-gliadin antigen. The results show that weight percentiles and intestinal absorption as assessed by xylose test are influenced by Gm(fb) phenotype suggesting that Gm(fb) genes contribute to the determination of clinical aspects and evolution of celiac disease.
我们研究了免疫球蛋白重链同种异型在乳糜泻发展过程中的作用。特别对Gm(fb)表型进行了研究，因为该表型能够决定针对α-麦醇溶蛋白抗原的免疫反应广度。结果显示，通过木糖试验评估的体重百分位数和肠道吸收受Gm(fb)表型影响，这表明Gm(fb)基因有助于确定乳糜泻的临床特征和病情发展。
