类风湿关节炎中的C3、Gm和Pi多态性
C3, Gm, and Pi polymorphisms in rheumatoid arthritis.
作者信息
Thomson W, Dyer P A, Sanders P A, Grennan D M
机构信息
Tissue Typing Laboratory, St Mary's Hospital, Manchester.
出版信息
Dis Markers. 1986 Jun;4(1-2):145-50.
PMID:3133151
Abstract
This paper reviews the associations between RA and three non-MHS genetic markers: C3, Gm, and Pi. There is no evidence to suggest that genes linked to C3 predispose to RA. However, there is evidence to suggest that genes on chromosome 14, linked to both Gm and Pi, do influence susceptibility to RA and further studies of this chromosome are indicated.
摘要
本文综述了类风湿关节炎（RA）与三种非主要组织相容性复合体（MHS）基因标记物：补体C3（C3）、免疫球蛋白重链Gm（Gm）和蛋白酶抑制物（Pi）之间的关联。没有证据表明与C3相关的基因易患RA。然而，有证据表明，位于14号染色体上与Gm和Pi均相关的基因确实会影响对RA的易感性，因此有必要对该染色体进行进一步研究。
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