The total synthesis of neoamphimedine.
作者信息
LaBarbera Daniel V, Bugni Tim S, Ireland Chris M
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
J Org Chem. 2007 Oct 26;72(22):8501-5. doi: 10.1021/jo7017813. Epub 2007 Sep 27.
Abstract
Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is the only member of more than one hundred pyridoacridines thus far to have this mechanism of action. Herein we report the first total synthesis of neoamphimedine.
摘要
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