Centro Tecnológico de la Carne de Galicia, Parque Tecnológico de Galicia, rúa Galicia No. 4, San Cibrao das Viñas, 32900 Ourense, Spain.
Centro de Tecnologia, Programa de Pós-Graduação em Ciência de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitária, Rio de Janeiro 21941-909, RJ, Brazil.
Mar Drugs. 2021 Jun 28;19(7):374. doi: 10.3390/md19070374.
Marine alkaloids comprise a class of compounds with several nitrogenated structures that can be explored as potential natural bioactive compounds. The scientific interest in these compounds has been increasing in the last decades, and many studies have been published elucidating their chemical structure and biological effects in vitro. Following this trend, the number of in vivo studies reporting the health-related properties of marine alkaloids has been increasing and providing more information about the effects in complex organisms. Experiments with animals, especially mice and zebrafish, are revealing the potential health benefits against cancer development, cardiovascular diseases, seizures, Alzheimer's disease, mental health disorders, inflammatory diseases, osteoporosis, cystic fibrosis, oxidative stress, human parasites, and microbial infections in vivo. Although major efforts are still necessary to increase the knowledge, especially about the translation value of the information obtained from in vivo experiments to clinical trials, marine alkaloids are promising candidates for further experiments in drug development.
海洋生物碱是一类含有多种含氮结构的化合物，可以作为潜在的天然生物活性化合物进行探索。在过去几十年中，人们对这些化合物的科学兴趣不断增加，许多研究已经发表，阐明了它们的化学结构和体外生物效应。随着这一趋势的发展，越来越多的体内研究报告了海洋生物碱的与健康相关的特性，提供了更多关于复杂生物体内效应的信息。动物实验，特别是小鼠和斑马鱼实验，揭示了海洋生物碱在预防癌症发展、心血管疾病、癫痫、阿尔茨海默病、心理健康障碍、炎症性疾病、骨质疏松症、囊性纤维化、氧化应激、人体寄生虫和微生物感染方面的潜在健康益处。尽管仍需要做出重大努力来增加相关知识，特别是关于从体内实验获得的信息转化为临床试验的价值，但海洋生物碱是药物开发进一步实验的有前途的候选物。
