Newman P J, Goldberger A
Baillieres Clin Haematol. 1991 Dec;4(4):869-88. doi: 10.1016/s0950-3536(06)80034-x.
Recent advances in molecular and cellular biology have made it possible to build upon previous serological and biochemical studies of human platelet alloantigen systems in important and exciting ways. In addition to providing a detailed basic understanding of the polymorphisms that are responsible for eliciting an alloimmune response, the molecular characterization of platelet membrane glycoprotein polymorphisms is expected to have an increasingly large clinical impact. As the molecular basis of the remaining platelet antigen systems becomes known, our ability to design novel diagnostic and therapeutic approaches for the care and management of patients with PTP and NATP should improve.
分子和细胞生物学的最新进展使得在以往人类血小板同种抗原系统的血清学和生物化学研究基础上，以重要且令人兴奋的方式取得进展成为可能。除了对引发同种免疫反应的多态性提供详细的基础理解之外，血小板膜糖蛋白多态性的分子特征预计将产生越来越大的临床影响。随着其余血小板抗原系统的分子基础为人所知，我们为血小板输注无效（PTP）和新生儿同种免疫血小板减少症（NATP）患者设计新型诊断和治疗方法以进行护理和管理的能力应该会有所提高。
