Barrett C T, Sevanian A, Lavin N, Kaplan S A
Pediatr Res. 1976 Jun;10(6):621-5. doi: 10.1203/00006450-197606000-00011.
Fetal lung cyclic AMP phosphodiesterase, cyclic AMP, phosphatidyl choline, and incorporation of precursors into phosphatidyl choline were measured in rabbits after maternal administration of hydrocortisone phosphate and aminophylline. Both agents inhibited lung phosphodiesterase activity and augmented cyclic AMP concentrations (Table 1). Aminophylline administration was associated with a significant increase in lung saturated phosphatidyl choline (Table 2). Incorporation of [14C] choline and [3H] methionine was increased by both aminophylline and hydrocortisone (Table 3).
在给孕兔静脉注射磷酸氢化可的松和氨茶碱后，检测其胎儿肺组织中环磷酸腺苷磷酸二酯酶、环磷酸腺苷、磷脂酰胆碱以及前体物质掺入磷脂酰胆碱的情况。两种药物均抑制肺组织磷酸二酯酶活性并提高环磷酸腺苷浓度（表1）。给予氨茶碱后肺组织饱和磷脂酰胆碱显著增加（表2）。氨茶碱和氢化可的松均使[14C]胆碱和[3H]蛋氨酸的掺入增加（表3）。
