FABP2基因T54等位基因与肥胖墨西哥人群心血管危险因素的关联。

Association of the T54 allele of the FABP2 gene with cardiovascular risk factors in obese Mexican subjects.

作者信息

Martínez-López Erika, Ruíz-Madrigal Bertha, Hernández-Cañaveral Iván, Panduro Arturo

机构信息

Service of Molecular Biology in Medicine, Civil Hospital of Guadalajara Fray Antonio Alcalde, PO Box 2-500, Guadalajara, Jalisco, Mexico 44280.

出版信息

Diab Vasc Dis Res. 2007 Sep;4(3):235-6. doi: 10.3132/dvdr.2007.046.

DOI:10.3132/dvdr.2007.046

PMID:17907115

Abstract

Genetic predisposition to cardiovascular risk may vary between different ethnic groups. We studied the effect of the FABP2 A54T polymorphism on biochemical and anthropometric cardiovascular risk factors in 114 obese Mexican subjects. The mean age of the patients studied was 36.8+/-13.3 years. Insulin resistance was present in 47%, hypercholesterolaemia in 49% and hypertriglyceridaemia in 45%. Frequency of the FABP2 genotype was 39% AA, 54.8% AT and 6.2% TT. The AT/TT group showed an increase in body mass index (34+/-7.1 vs. 31+/-4.8 kg/m2), waist circumference (101+/-15.7 vs. 96.5+/-15.8 cm), triglycerides (145+/-60.8 vs. 127+/-79.4 mg/dL; 1.64+/-0.67 vs. 1.43+/-0.89 mmol/L), total cholesterol (176+/-39.4 vs. 164+/-38.2 mg/dL; 4.55+/-1.02 vs. 4.24+/-0.99 mmol/L), LDL (121+/-24.2 vs. 111+/-25.9 mg/dL; 3.13+/-0.62 vs. 2.88+/-0.67 mmol/L) and VLDL (28.8+/-12.1 vs. 25.1+/-16.1 mg/dL; 0.74+/-0.31 vs. 0.64+/-0.41 mmol/L) compared to the AA group (p<0.05). The AT/TT group had greatly increased cardiovascular risk, with an OR of 7.56 (95% CI, 1.82-36.24; p<0.001) compared to the AA group. Our results suggest that A54T polymorphism of the FABP2 gene is associated with cardiovascular disease risk in obese subjects.

摘要

心血管疾病风险的遗传易感性在不同种族群体之间可能存在差异。我们研究了FABP2基因A54T多态性对114名肥胖墨西哥受试者生化和人体测量学心血管疾病风险因素的影响。所研究患者的平均年龄为36.8±13.3岁。47%的患者存在胰岛素抵抗，49%的患者有高胆固醇血症，45%的患者有高甘油三酯血症。FABP2基因的基因型频率为：AA型39%，AT型54.8%，TT型6.2%。与AA组相比，AT/TT组的体重指数（34±7.1 vs. 31±4.8 kg/m2）、腰围（101±15.7 vs. 96.5±15.8 cm）、甘油三酯（145±60.8 vs. 127±79.4 mg/dL；1.64±0.67 vs. 1.43±0.89 mmol/L）、总胆固醇（176±39.4 vs. 164±38.2 mg/dL；4.55±1.02 vs. 4.24±0.99 mmol/L）、低密度脂蛋白（121±24.2 vs. 111±25.9 mg/dL；3.13±0.62 vs. 2.88±0.67 mmol/L）和极低密度脂蛋白（28.8±12.1 vs. 25.1±16.1 mg/dL；0.74±0.31 vs. 0.64±0.41 mmol/L）均有所升高（p<0.05）。与AA组相比，AT/TT组的心血管疾病风险大幅增加，比值比为7.56（95%置信区间，1.82 - 36.24；p<0.001）。我们的研究结果表明，FABP2基因的A54T多态性与肥胖受试者的心血管疾病风险相关。