Lane Nancy E, Nevitt Michael C, Lui Li-Yung, de Leon Patricia, Corr Maripat
University of California, Davis, Sacramento, CA 95817, USA.
Arthritis Rheum. 2007 Oct;56(10):3319-25. doi: 10.1002/art.22867.
To determine whether serum levels of 2 Wnt signaling antagonists, Frizzled-related protein (FRP) and Dkk-1, are associated with the development and progression of radiographic hip osteoarthritis (RHOA).
Pelvic radiographs were obtained a mean of 8.3 years apart in 5,928 Caucasian women >or=65 years of age who were enrolled in the Study of Osteoporotic Fractures. Random sampling of this cohort was performed, with approximately 180 subjects per group assigned to 2 nested case-control studies on RHOA incidence and progression. Baseline serum levels of FRP and Dkk-1 were measured by capture enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression analyses with adjustment for potential covariates.
There were no differences in serum levels of FRP and Dkk-1 between case subjects with incidence or progression of RHOA and their respective control subjects. There was a trend for higher baseline serum levels of FRP to be associated with a reduced risk of incident RHOA (age-adjusted OR 0.59 [95% CI 0.32-1.09], P = 0.09 for women in the highest quartile versus women in the lowest quartile). There was no association of serum levels of FRP with progression of RHOA. Serum levels of Dkk-1 did not correlate with incident RHOA. However, higher serum levels of Dkk-1 were associated with diminished risk of RHOA progression (age-adjusted OR 0.43 [95% CI 0.23-0.79], P = 0.007 for women in the highest quartile compared with women in the lowest quartile).
Elevated circulating levels of Dkk-1 appeared to be associated with reduced progression of RHOA in elderly women, whereas the highest quartile of serum FRP levels tended to be associated with a modest reduction in risk of incident RHOA.
确定两种Wnt信号拮抗剂——卷曲相关蛋白（FRP）和 Dickkopf-1（Dkk-1）的血清水平是否与影像学髋关节骨关节炎（RHOA）的发生和进展相关。
对纳入骨质疏松性骨折研究的5928名年龄≥65岁的白人女性，平均间隔8.3年获取骨盆X线片。对该队列进行随机抽样，每组约180名受试者被分配到两项关于RHOA发病率和进展的嵌套病例对照研究中。通过捕获酶联免疫吸附测定法测量FRP和Dkk-1的基线血清水平。使用逻辑回归分析计算比值比（OR）和95%置信区间（95%CI），并对潜在协变量进行调整。
RHOA发病或进展的病例组与各自对照组之间，FRP和Dkk-1的血清水平无差异。FRP基线血清水平较高有与RHOA发病风险降低相关的趋势（最高四分位数女性与最低四分位数女性相比，年龄调整后的OR为0.59[95%CI 0.32 - 1.09]，P = 0.09）。FRP血清水平与RHOA进展无关联。Dkk-1血清水平与RHOA发病无相关性。然而，较高的Dkk-1血清水平与RHOA进展风险降低相关（最高四分位数女性与最低四分位数女性相比，年龄调整后的OR为0.43[95%CI 0.23 - 0.79]，P = 0.007）。
循环中Dkk-1水平升高似乎与老年女性RHOA进展减缓相关，而血清FRP水平最高四分位数往往与RHOA发病风险适度降低相关。
