Azzam Adel Ibrahim, Labib Abdelrahman Mohamed, Haseeb Abd-Elshafy Ahmed, Abd-Elaziz Ahmed Fathy
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
J Med Ultrasound. 2024 Jun 21;33(1):29-34. doi: 10.4103/jmu.jmu_139_23. eCollection 2025 Jan-Mar.
Osteoarthritis (OA) is a frequently complex joint disease that involves all joint components, including cartilage degeneration and new bone development. Dickkopf-1 (Dkk-1) regulates bone growth and repair in OA. The purpose of this study is to determine Dkk-1 blood levels in individuals with primary knee joint OA, as well as their associations with disease progression and severity.
This study included 45 individuals with primary OA of the knee and 45 healthy participants. Demographic data, body mass index, Visual Analog Scale, and Western Ontario and McMaster Universities Arthritis questionnaire scores were gathered. On radiography, the Kellgren and Lawrence score was acquired. The knee joint ultrasonography results were documented. The blood level of Dkk-1 was determined using the enzyme-linked immunosorbent assay method.
Dkk-1 levels in the blood were substantially higher in patients with OA than in healthy persons. Serum Dkk-1 levels appeared to have a significantly inverted relationship with radiological OA grades in knee OA ( < 0.001). Dkk-1 serum levels were significantly lower in individuals with ultrasonographic knee effusion (median = 3.2, interquartile range [IQR] = 3.1-4.16) than in those without effusion (median = 4.79, IQR = 4.04-5.09). Furthermore, there was a strong correlation between Dkk-1 levels and ultrasonographically measured femoral cartilage thickness.
Dkk-1 is an interesting radiological indicator associated with degenerative articular joint disease. It may have a crucial function in slowing the process of degeneration in knee OA and reflecting the disease's radiographic and clinical severity.
骨关节炎（OA）是一种常见的复杂关节疾病，累及所有关节成分，包括软骨退变和新骨形成。Dickkopf-1（Dkk-1）在OA中调节骨生长和修复。本研究的目的是确定原发性膝关节OA患者的Dkk-1血液水平，以及它们与疾病进展和严重程度的关联。
本研究纳入45例原发性膝关节OA患者和45名健康参与者。收集人口统计学数据、体重指数、视觉模拟评分以及西安大略和麦克马斯特大学骨关节炎问卷评分。通过X线摄影获得Kellgren和Lawrence评分。记录膝关节超声检查结果。采用酶联免疫吸附测定法测定Dkk-1的血液水平。
OA患者血液中的Dkk-1水平显著高于健康人。在膝关节OA中，血清Dkk-1水平与放射学OA分级呈显著负相关（<0.001）。超声检查发现膝关节积液的患者血清Dkk-1水平（中位数=3.2，四分位间距[IQR]=3.1-4.16）显著低于无积液患者（中位数=4.79，IQR=4.04-5.09）。此外，Dkk-1水平与超声测量的股骨软骨厚度之间存在强相关性。
Dkk-1是一种与退行性关节疾病相关的有趣的放射学指标。它可能在减缓膝关节OA的退变过程以及反映疾病的放射学和临床严重程度方面具有关键作用。
