Ochoa M C, Moreno-Aliaga M J, Martínez-González M A, Martínez J A, Marti A
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Int J Pediatr Obes. 2006;1(2):83-8. doi: 10.1080/17477160600650386.
A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk.
Obese (n=165) and control subjects (n=165) matched by sex and age were recruited and classified according to Spanish reference data. Results. Using conditional logistic regression, we calculated the obesity risk linked to the polymorphism. A statistically significant association was found for 27Glu carrier allele girls (OR = 1.95; 95% CI = 1.02-3.70), but no association was apparent among boys. In the fully adjusted model, the odds ratio for obesity linked to the genotype Glu27Glu in the female population rose to 4.84 (95% CI = 1.37-17.10). Moreover, we found a significant negative interaction between hours of TV watching and the Gln27Glu polymorphism for obesity risk in girls. Surprisingly, among 27Glu carrier subjects, even girls with a low level of TV watching ( < 12.5 h/week) had a high obesity risk (OR = 4.60; 95% CI = 1.01-20.02), which was not very different to the odds ratio values for sedentary girls carrying the 27 Glu allele watching TV more than 12.5 h/week (OR = 6.05; 95% CI = 1.31-27.71). Conclusion. A higher risk of obesity was found for girls carrying the 27Glu allele of the ADRB2 gene even when they spent less than 12.5 h/week watching TV. In addition, our results suggest that the effect of sedentary lifestyle on obesity risk may depend on the genotype of the subject.
在西班牙儿童和青少年（5 - 18岁）人群中开展一项配对病例对照研究，以评估ADRB2基因的Gln27Glu多态性与看电视对肥胖风险的相互作用。
招募了按性别和年龄匹配的肥胖患者（n = 165）和对照受试者（n = 165），并根据西班牙参考数据进行分类。结果。使用条件逻辑回归，我们计算了与该多态性相关的肥胖风险。发现携带27Glu等位基因的女孩存在统计学显著关联（OR = 1.95；95% CI = 1.02 - 3.70），但男孩中未发现明显关联。在完全调整模型中，女性人群中与Glu27Glu基因型相关的肥胖比值比升至4.84（95% CI = 1.37 - 17.10）。此外，我们发现女孩看电视时长与Gln27Glu多态性对肥胖风险存在显著负向相互作用。令人惊讶的是，在携带27Glu等位基因的受试者中，即使是每周看电视时间较少（< 12.5小时/周）的女孩也有较高的肥胖风险（OR = 4.60；95% CI = 1.01 - 20.02），这与每周看电视超过12.5小时/周的携带27Glu等位基因的久坐女孩的比值比数值（OR = 6.05；95% CI = 1.31 - 27.71）没有太大差异。结论。即使每周看电视时间少于12.5小时，携带ADRB2基因27Glu等位基因的女孩肥胖风险更高。此外，我们的结果表明久坐生活方式对肥胖风险的影响可能取决于受试者的基因型。
