Martin-Calvo Nerea, Martínez-González Miguel-Angel, Bes-Rastrollo Maira, Gea Alfredo, Ochoa Ma Carmen, Marti Amelia
1Department of Preventive Medicine & Public Health,School of Medicine,University of Navarra,C/Irunlarrea 1,31008 Pamplona,Spain.
3Centro de Investigación Medica Aplicada (CIMA),Pamplona,Spain.
Public Health Nutr. 2014 Oct;17(10):2185-93. doi: 10.1017/S136898001300356X. Epub 2014 Jan 31.
To assess the association between the consumption of sugar-sweetened carbonated beverages (SSCB) and obesity in children and adolescents from Navarra (Spain).
We used a matched case-control study design. The exposure, SSCB consumption (1 serving: 200 ml), was measured with a previously validated FFQ. Anthropometrical measures were taken using standardized protocols. The outcome, obesity, was defined as BMI above the age- and sex-specific 97th percentile according to the Spanish reference charts. In the analysis we used conditional logistic regression. Potential confounders were controlled using a multivariable model.
Subjects were recruited in the paediatric departments of the Universidad de Navarra Clinic and the Navarra Hospital Complex, and in three primary health centres of Navarra. Controls were recruited when attending for a routine medical examination or vaccination.
One hundred and seventy-four obese children and 174 individually sex- and age-matched controls, 52·87% boys, with a mean age of 11·6 years. Exclusion criteria were dietary interventions, exposure to hormone treatment, development of secondary obesity due to endocrinopathy and serious intercurrent illness.
Independently of other factors, high consumption of SSCB (>4 servings/week) was significantly associated with obesity (OR = 3·46; 95% CI 1·24, 9·62; P = 0·01). Besides, each additional daily serving of SSCB was associated with a 69% relative increase in the risk of obesity (OR = 1·69; 95% CI 1·04, 2·73; P = 0·03).
We found a strong and significant association between SSCB consumption and obesity risk. Our results suggest a monotonic dose-response linear shape for this association in children and adolescents (P for trend = 0·02).
评估西班牙纳瓦拉地区儿童和青少年饮用含糖碳酸饮料(SSCB)与肥胖之间的关联。
采用匹配病例对照研究设计。通过先前验证的食物频率问卷(FFQ)测量暴露因素,即SSCB的饮用量(1份:200毫升)。使用标准化方案进行人体测量。结局指标肥胖根据西班牙参考图表定义为体重指数(BMI)高于年龄和性别特异性的第97百分位数。在分析中,我们使用条件逻辑回归。通过多变量模型控制潜在混杂因素。
研究对象在纳瓦拉大学诊所和纳瓦拉医院综合院区的儿科部门以及纳瓦拉的三个初级卫生中心招募。对照在进行常规体检或接种疫苗时招募。
174名肥胖儿童和174名个体性别和年龄匹配的对照,男孩占52.87%,平均年龄11.6岁。排除标准包括饮食干预、接受激素治疗、因内分泌病导致继发性肥胖以及严重并发疾病。
独立于其他因素,高SSCB饮用量(>4份/周)与肥胖显著相关(比值比[OR]=3.46;95%置信区间[CI]1.24,9.62;P=0.01)。此外,每天额外饮用一份SSCB与肥胖风险相对增加69%相关(OR=1.69;95%CI1.04,2.73;P=0.03)。
我们发现饮用SSCB与肥胖风险之间存在强烈且显著的关联。我们的结果表明,在儿童和青少年中,这种关联呈单调剂量反应线性关系(趋势P值=0.02)。