Gorenkov R V, Karpov B N, Rogatkin D A, Shumskiĭ V I
Biofizika. 2007 Jul-Aug;52(4):711-7.
The hypothesis about the influence of chronic hypoxia in soft alive tissues on the intensity of He-Ne laser-induced fluorescence of endogenous porphyrins in tissues in the red region of the optical spectrum is discussed. Some theoretical prerequisites for enormous accumulation of porphyrins in soft tissues in a number of pathological cases and diseases are presented. A method for conducting clinical experimental trials to verify the hypothesis with the use of up-to-date laser noninvasive fluorescent diagnostics is proposed. Both the theoretical reasoning and new clinical experimental data show that chronic hypoxia can be one of the factors responsible for the appearance of a strong and abnormal laser-induced fluorescent signal from biotissues in the spectrum range 600-800 nm, which is associated with abnormally high accumulation of endogenous porphyrins in tissues.
讨论了关于慢性缺氧对柔软活体组织中内源性卟啉在光谱红色区域的氦氖激光诱导荧光强度影响的假说。提出了在一些病理情况和疾病中卟啉在软组织中大量积累的一些理论前提。提出了一种利用最新的激光无创荧光诊断技术进行临床试验以验证该假说的方法。理论推理和新的临床实验数据均表明，慢性缺氧可能是导致生物组织在600 - 800 nm光谱范围内出现强烈且异常的激光诱导荧光信号的因素之一，这与组织中内源性卟啉的异常高积累有关。
