Rehni Ashish K, Pantlya Hardeep S, Shri Richa, Singh Manjeet
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, Punjab, India.
Indian J Exp Biol. 2007 Sep;45(9):764-9.
Bilateral carotid artery occlusion followed by reperfusion produced significant cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. Individual pretreatments with chlorophyll and aqueous extracts of B. monniera and V. wallichii markedly attenuated ischaemia-reperfusion induced cerebral injury in terms of decreased infarct size, increase in short-term memory, motor in coordination and lateral push response. The results suggest that chlorophyll and aqueous extracts of B. monniera and V. wallichii prevent ischaemia-reperfusion induced cerebral injury with comparable potency.
双侧颈动脉闭塞后再灌注会导致显著的脑梗死，并损害短期记忆、运动协调能力和侧推反应。单独用叶绿素以及印度獐牙菜和瓦氏缬草的水提取物进行预处理，在梗死面积减小、短期记忆增加、运动协调性和侧推反应方面，均显著减轻了缺血再灌注诱导的脑损伤。结果表明，叶绿素以及印度獐牙菜和瓦氏缬草的水提取物预防缺血再灌注诱导的脑损伤的效力相当。
