Segal Alissa R, Doherty Kevin M, Leggott John, Zlotoff Barrett
Massachusetts College of Pharmacy & Health Sciences, Department of Pharmacy Practice, 179 Longwood Ave, Boston, MA 02115-5896, USA.
Pediatrics. 2007 Oct;120(4):e1082-96. doi: 10.1542/peds.2005-2321.
Cutaneous eruptions are a commonly reported adverse drug reaction. Cutaneous adverse drug reactions in the pediatric population have a significant impact on patients' current and future care options. A patient's recollection of having a "rash" when they took a medication as a child is a frequent reason for not prescribing a particular treatment. The quick detection and treatment of cutaneous adverse drug reactions, plus identification of the causative agent, are essential for preventing the progression of the reaction, preventing additional exposures, and ensuring the appropriate use of medications for both the current condition and others as the patient ages. The purpose of this review is to discuss a reasonable approach to recognition and initial management of cutaneous adverse drug reactions in children.
皮肤疹是一种常见的药物不良反应。儿科人群中的皮肤药物不良反应对患者当前和未来的治疗选择有重大影响。患者回忆起小时候服药时出现“皮疹”,这是不处方某种特定治疗的常见原因。快速检测和治疗皮肤药物不良反应,以及确定致病因素,对于防止反应进展、避免再次接触以及确保患者在当前病情和随着年龄增长治疗其他疾病时合理用药至关重要。本综述的目的是讨论一种识别和初步处理儿童皮肤药物不良反应的合理方法。