环孢素治疗严重泛发性大疱性固定性药疹：1例报告及文献复习
Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review.
作者信息
Barootes Hailey C, Peebles Erin R, Matsui Doreen, Rieder Michael, Abuzgaia Awatif, Mohammed Javed A
机构信息
Department of Paediatrics, Children's Hospital, London Health Sciences Centre, Western University, London, Ontario, Canada.
Department of Paediatrics, Division of Paediatric Clinical Pharmacology, Children's Hospital, London Health Sciences Centre, Robarts Research Institute, Western University, London, Ontario, Canada.
出版信息
Case Rep Dermatol. 2021 Mar 3;13(1):154-163. doi: 10.1159/000513469. eCollection 2021 Jan-Apr.
Generalized bullous fixed drug eruptions (GBFDEs) are rare in the paediatric population. We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first report of a paediatric case of GBFDE treated with cyclosporine. In our report, we review published cases of GBFDE in children, and all adult cases managed with cyclosporine.
泛发性大疱性固定型药疹（GBFDEs）在儿科人群中较为罕见。我们报告了一例7岁患有GBFDE的女孩，据信该病继发于口服布洛芬，在接受为期3周的口服环孢素治疗后，皮损迅速消退且水疱停止出现。据我们所知，这是首例使用环孢素治疗儿童GBFDE的报告。在我们的报告中，我们回顾了已发表的儿童GBFDE病例以及所有使用环孢素治疗的成人病例。
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