规律的体育活动会影响青春期女孩的血浆胃饥饿素浓度。

Regular physical activity influences plasma ghrelin concentration in adolescent girls.

作者信息

Jürimäe Jaak, Cicchella Antonio, Jürimäe Toivo, Lätt Evelin, Haljaste Kaja, Purge Pritt, Hamra Jena, von Duvillard Serge P

机构信息

Institute of Sport Pedagogy and Coaching Sciences, Center of Behavioral and Health Sciences, University of Tartu, Tartu, Estonia.

出版信息

Med Sci Sports Exerc. 2007 Oct;39(10):1736-41. doi: 10.1249/mss.0b013e31812e5294.

DOI:10.1249/mss.0b013e31812e5294

PMID:17909400

Abstract

PURPOSE

We examined the effect of regular physical activity on plasma ghrelin concentration after onset of puberty in girls. In addition, we also examined the association of fasting plasma ghrelin concentration with various plasma biochemical, body composition, and aerobic capacity variables in healthy adolescent girls.

METHOD

Fifty healthy schoolgirls ages 11 to 16 yr were divided either into a physically active (N = 25) or a physically inactive (N = 25) group. The physically active group consisted of swimmers who had trained on an average of 6.2 +/- 2.0 h.wk(-1) for the last 2 yr, whereas the inclusion criterion for the physically inactive group was the participation in physical education classes only. The subjects were matched for age (+/- 1 yr) and body mass index (BMI; +/- 2 kg.m(-2)). Maturation I group (14 matched pairs) included pubertal stages 2 and 3, and maturation II group (11 matched pairs) included pubertal stages 4 and 5.

RESULTS

Physically active girls had significantly higher (P < 0.05) mean plasma ghrelin levels than the physically inactive girls (maturation I: 1152.1 +/- 312.9 vs 877.7 +/- 114.8 pg.mL(-1); maturation II: 1084.0 +/- 252.5 vs 793.4 +/- 164.9 pg.mL(-1)). Plasma ghrelin concentration was negatively related to percent body fat, fat mass, peak oxygen consumption per kilogram of body mass, leptin, estradiol, insulin, and insulin-like growth factor-I (IGF-I) (r > -0.298; P < 0.05). Multivariate linear regression analysis to determine the predictors of ghrelin concentration using the variables that were significantly associated with ghrelin concentration demonstrated that plasma IGF-I was the most important predictor of plasma ghrelin concentration (beta = -0.396; P = 0.008).

CONCLUSION

Regular physical activity influences plasma ghrelin concentrations in girls with different pubertal maturation levels. Plasma IGF-I concentration seems to be the main determinant of circulating ghrelin in healthy, normal-weight adolescent girls.

摘要

目的

我们研究了规律体育活动对女孩青春期开始后血浆胃饥饿素浓度的影响。此外，我们还研究了健康青春期女孩空腹血浆胃饥饿素浓度与各种血浆生化指标、身体成分及有氧能力变量之间的关联。

方法

将50名年龄在11至16岁的健康女学生分为体育活动组（N = 25）和体育不活动组（N = 25）。体育活动组由游泳运动员组成，她们在过去2年中平均每周训练6.2 +/- 2.0小时，而体育不活动组的纳入标准是仅参加体育课。受试者在年龄（±1岁）和体重指数（BMI；±2 kg·m⁻²）方面进行了匹配。成熟I组（14对匹配）包括青春期2期和3期，成熟II组（11对匹配）包括青春期4期和5期。

结果

体育活动的女孩比体育不活动的女孩平均血浆胃饥饿素水平显著更高（P < 0.05）（成熟I组：1152.1 +/- 312.9 vs 877.7 +/- 114.8 pg·mL⁻¹；成熟II组：1084.0 +/- 252.5 vs 793.4 +/- 164.9 pg·mL⁻¹）。血浆胃饥饿素浓度与体脂百分比、脂肪量、每千克体重的峰值耗氧量、瘦素、雌二醇、胰岛素和胰岛素样生长因子-I（IGF-I）呈负相关（r > -0.298；P < 0.05）。使用与胃饥饿素浓度显著相关的变量进行多变量线性回归分析以确定胃饥饿素浓度的预测因素，结果表明血浆IGF-I是血浆胃饥饿素浓度的最重要预测因素（β = -0.396；P = 0.008）。