Carletti Barbara, Rossi Ferdinando
Department of Neuroscience and Rita Levi Montalcini Centre for Brain Repair, National Institute of Neuroscience, University of Turin, Italy.
Neuroscientist. 2008 Feb;14(1):91-100. doi: 10.1177/1073858407304629. Epub 2007 Oct 2.
In the past few years, genetic fate mapping experiments have changed our vision of cerebellar development, particularly in redefining the origin of gabaergic and glutamatergic neurons of the cerebellar cortex and highlighting the precise spatio-temporal sequence of their generation. Here the authors review cerebellar neurogenesis and discuss the fate mapping studies with other new information stemming from transplantation experiments, in an effort to link the developmental potential of neural progenitor populations of the cerebellum with their spatio-temporal origin.
在过去几年中,遗传命运图谱实验改变了我们对小脑发育的看法,特别是在重新定义小脑皮质中γ-氨基丁酸能和谷氨酸能神经元的起源,并突出它们产生的精确时空顺序方面。本文作者回顾了小脑神经发生,并结合移植实验产生的其他新信息讨论了命运图谱研究,以期将小脑神经祖细胞群的发育潜能与其时空起源联系起来。