Neuroscience Institute of Turin (NIT), Department of Neuroscience, University of Turin, Turin, Italy.
Cerebellum. 2012 Jun;11(2):434-5. doi: 10.1007/s12311-011-0324-8.
Cerebellar GABAergic projection neurons and interneurons originate from the ventricular neuroepithelium of the cerebellar primordium. However, while projection neurons are born within this germinal layer, interneurons derive from progenitors that delaminate into the prospective white matter. In spite of this common origin, the two main classes of GABAergic neurons are generated according to distinct strategies. Projection neurons are committed to their fate at early ontogenetic stages and acquire their mature phenotypes through cell-autonomous mechanisms. On the contrary, the different categories of cerebellar interneurons derive from a single pool of multipotent progenitors, whose fate choices, production rates and differentiation schedules are strongly influenced by environmental cues.
小脑 GABA 能投射神经元和中间神经元起源于小脑原基的脑室神经上皮。然而，虽然投射神经元在这个生发层中产生，但中间神经元来自于脱离到预期白质的祖细胞。尽管有这种共同的起源，但两种主要的 GABA 能神经元类群是根据不同的策略产生的。投射神经元在早期胚胎发生阶段就决定了它们的命运，并通过细胞自主机制获得成熟表型。相反，小脑中间神经元的不同类别来自于一个多能祖细胞的单一池，其命运选择、产生率和分化时间表受到环境线索的强烈影响。
