马肝醇脱氢酶通过动态动力学拆分对芳基丙酸醛进行高效不对称还原。
Highly efficient asymmetric reduction of arylpropionic aldehydes by horse liver alcohol dehydrogenase through dynamic kinetic resolution.
作者信息
Giacomini Daria, Galletti Paola, Quintavalla Arianna, Gucciardo Gabriele, Paradisi Francesca
机构信息
Department of Chemistry G. Ciamician, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy.
出版信息
Chem Commun (Camb). 2007 Oct 21(39):4038-40. doi: 10.1039/b712290j. Epub 2007 Sep 10.
The enantioselective synthesis of (2S)-2-phenylpropanol and (2S)-2-(4-iso-butylphenyl)propanol ((S)-Ibuprofenol) has been achieved by means of Horse Liver Alcohol Dehydrogenase (HLADH) in buffered aqueous solution or buffered organic solvent mixtures; under the reaction conditions, a dynamic kinetic resolution (DKR) process was realized with good reaction yields and enantiomeric ratios.
通过马肝醇脱氢酶（HLADH）在缓冲水溶液或缓冲有机溶剂混合物中实现了（2S）-2-苯基丙醇和（2S）-2-（4-异丁基苯基）丙醇（（S）-布洛芬醇）的对映选择性合成；在反应条件下，实现了动态动力学拆分（DKR）过程，反应产率和对映体比例良好。
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