来自黄斑叶石耳和南蛇藤石蕊培养地衣共生菌的地衣次生代谢产物及其抗病毒活性。

Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.

作者信息

Fazio Alejandra T, Adler Mónica T, Bertoni María D, Sepúlveda Claudia S, Damonte Elsa B, Maier Marta S

机构信息

Laboratorio de Liquenología, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentin.

出版信息

Z Naturforsch C J Biosci. 2007 Jul-Aug;62(7-8):543-9. doi: 10.1515/znc-2007-7-813.

DOI:10.1515/znc-2007-7-813

PMID:17913069

Abstract

Lichens and spore-derived cultured mycobionts of Teloschistes chrysophthalmus and Ramalina celastri were studied chemically, and results indicated that they produced, respectively, parietin and usnic acid as major secondary metabolites, which were purified and identified. Identification of the compounds was performed by high performance liquid chromatography and structural elucidation by nuclear magnetic resonance (1H) and electron impact mass spectrometry. Usnic acid exhibited antiviral activity whereas parietin had a virucidal effect against the arenaviruses Junin and Tacaribe.

摘要

对黄斑地图衣和南蛇藤石蕊的地衣体以及孢子衍生的培养共生菌进行了化学研究，结果表明它们分别产生了壁酸和松萝酸作为主要次生代谢产物，并对其进行了纯化和鉴定。化合物的鉴定通过高效液相色谱法进行，结构解析通过核磁共振（1H）和电子轰击质谱法进行。松萝酸表现出抗病毒活性，而壁酸对沙粒病毒胡宁病毒和塔卡里贝病毒具有杀病毒作用。