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类菌生物次级代谢产物的抗血管生成特性。

Antiangiogenic properties of lichen secondary metabolites.

机构信息

Department of Biology, Faculty of Science, Ege University, Izmir, Turkey.

出版信息

Phytother Res. 2021 Jun;35(6):3046-3058. doi: 10.1002/ptr.7023. Epub 2021 Feb 15.

Abstract

Lichens are symbiotic organisms which are composed fungi and algae and/or cyanobacteria. They produce a variety of characteristic secondary metabolites. Such substances have various biological properties including antimicrobial, antiviral, and antitumor activities. Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, atherosclerosis, infectious, and immune disorders. Antiangiogenic therapy is a promising approach for the treatment of such diseases by inhibiting the new vessel formation. Technological advances have led to the development of various antiangiogenic agents and have made possible antiangiogenic therapy in many diseases associated with angiogenesis. Some lichens and their metabolites are used in the drug industry, but many have not yet been tested for their antiangiogenic effects. The cytotoxic and angiogenic capacities of lichen-derived small molecules have been demonstrated in vivo and in vitro experiments. Therefore, some of them may be used as antiangiogenic agents in the future. The secondary compounds of lichen whose antiangiogenic effect has been studied in the literature are usnic acid, barbatolic acid, vulpinic acid, olivetoric acid, emodin, secalonic acid D, and parietin. In this article, we review the antiangiogenic effects and cellular targets of these lichen-derived metabolites.

摘要

地衣是由真菌和藻类以及/或蓝细菌共生组成的生物体。它们产生各种特征性的次生代谢物。这些物质具有多种生物特性,包括抗菌、抗病毒和抗肿瘤活性。血管生成是指新血管从预先存在的血管中生长,它与许多疾病有关,包括癌症、关节炎、动脉粥样硬化、感染和免疫紊乱。抗血管生成治疗是通过抑制新血管形成来治疗这些疾病的一种有前途的方法。技术进步导致了各种抗血管生成剂的发展,并使许多与血管生成相关的疾病能够进行抗血管生成治疗。一些地衣及其代谢物被用于药物工业,但许多尚未测试其抗血管生成作用。地衣衍生的小分子的细胞毒性和血管生成能力已在体内和体外实验中得到证实。因此,它们中的一些可能在未来被用作抗血管生成剂。在文献中研究过具有抗血管生成作用的地衣次生化合物有地衣酸、巴伐他酸、漆酚酸、橄榄苦苷酸、大黄素、secalonic 酸 D 和扁柏素。本文综述了这些地衣衍生代谢物的抗血管生成作用和细胞靶点。

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