Van Biervliet S, Van Biervliet J P, Vande Velde S, Robberecht E
Paediatric Department, Ghent University Hospital, UZ Ghent, De Pintelaan 185, Ghent 9000, Belgium.
Biol Trace Elem Res. 2007 Oct;119(1):19-26. doi: 10.1007/s12011-007-0041-9.
Assess the risk of zinc (Zn) deficiency in the older cystic fibrosis (CF) population.
Cross-sectional investigation of all CF patients above the age of 4 followed at the Ghent University center between 2002 and 2003. Data on age, weight, height z-score, pancreatic and pulmonary functions, chronic Pseudomonas infection, and CF transmembrane conductance regulator (CFTR) mutations were collected. Serum Zn, vitamins (vit) A and E, retinol-binding protein (RBP), albumin, sedimentation rate, total IgG, and cholesterol were determined. Serum Zn was compared with a local healthy control group (Van Biervliet et al., Biol Trace Elem Res 94:33-40, 2003) and with literature data (Hotz C, et al. Am J Clin Nutr 78:756-764, 2003).
101 patients (median age 16 years) were included. There was no difference in serum Zn concentration between CF patients and controls. In CF patients no difference in serum Zn concentration between pancreatic-sufficient or pancreatic-insufficient patients was seen. Serum Zn was not associated to nutritional status or height z-score. A significant association serum Zn to serum albumin (p < 0.0005) and to vit A (p < 0.01) was seen. No associations of serum Zn to serum vit E, RBP, cholesterol, or CFTR were present, but there is a significant association serum Zn to forced vital capacity (p < 0.01). Serum Zn was not associated to inflammatory parameters or chronic Pseudomonas infection.
Comparison of CF patients with local controls revealed no significant differences. However, because persisting steatorrhea increases Zn loss (Easley et al., J Pediatr Gastroenterol Nutr 26:136-139, 1998) and 12.6% of our population has a serum Zn below the p value of 2.5 of the NHANES II study (Hotz C, et al. Am J Clin Nutr 78:756-764, 2003), there could remain an increased risk of Zn deficiency in some CF patients. Furthermore, the association with pulmonary function needs more investigation.
评估老年囊性纤维化（CF）患者锌（Zn）缺乏的风险。
对2002年至2003年间在根特大学中心随访的所有4岁以上CF患者进行横断面调查。收集年龄、体重、身高Z评分、胰腺和肺功能、慢性铜绿假单胞菌感染以及CF跨膜传导调节因子（CFTR）突变的数据。测定血清锌、维生素（vit）A和E、视黄醇结合蛋白（RBP）、白蛋白、血沉、总IgG和胆固醇。将血清锌与当地健康对照组（Van Biervliet等人，《生物微量元素研究》94:33 - 40，2003年）以及文献数据（Hotz C等人，《美国临床营养学杂志》78:756 - 764，2003年）进行比较。
纳入101例患者（中位年龄16岁）。CF患者与对照组之间血清锌浓度无差异。在CF患者中，胰腺功能正常或胰腺功能不全患者之间血清锌浓度无差异。血清锌与营养状况或身高Z评分无关。血清锌与血清白蛋白（p < 0.0005）和维生素A（p < 0.01）存在显著关联。血清锌与血清维生素E、RBP、胆固醇或CFTR无关联，但血清锌与用力肺活量存在显著关联（p < 0.01）。血清锌与炎症参数或慢性铜绿假单胞菌感染无关。
CF患者与当地对照组比较无显著差异。然而，由于持续性脂肪泻会增加锌的流失（Easley等人，《儿科学胃肠病学与营养杂志》26:136 - 139，1998年），且我们研究人群中有１２.６％的血清锌低于美国国家健康与营养检查调查（NHANES）II研究中第2.5百分位数的p值（Hotz C等人，《美国临床营养学杂志》78:756 - 764，2003年），部分CF患者可能仍存在锌缺乏风险增加的情况。此外，锌与肺功能的关联需要更多研究。
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