Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain.
Department of Analytical Chemistry, Science Faculty, University of Valladolid, Campus Miguel Delibes, Calle Paseo de Belén, 7, 47011 Valladolid, Spain.
Nutrients. 2019 Jan 11;11(1):150. doi: 10.3390/nu11010150.
Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings.
The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients.
A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted. Hypozincemia was determined by SZC while using atomic absorption spectrophotometry and dietary zinc deficiency by prospective 72-h dietary surveys.
Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Three of 17 patients with CF (17.6%) had hypozincemia and four (23.5%) had a dietary zinc deficiency. No patient with dietary zinc deficiency had hypozincemia. A positive and significant association was observed between SZC and Z-score of BMI-for-age ( = 0.048) and weight-for-height ( = 0.012) and between dietary zinc intake and energy intake (EI, = 0.036) and Z-score of weight-for-high ( = 0.029).
SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. No patient with hypozincemia had dietary zinc deficiency. This situation should alert us to a marginal zinc deficiency and it may explain why there were no overlapping cases between the two groups. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered.
锌是所有生命形式的必需营养素，其缺乏会影响人类的正常生长发育。
本研究旨在通过血清锌浓度（SZC）和膳食锌摄入量来调查囊性纤维化（CF）患者的锌营养状况及其相关性。
对 CF 患者进行横断面研究。进行人体测量和呼吸及胰腺功能检查。采用原子吸收分光光度法测定 SZC 来确定低锌血症，采用前瞻性 72 小时膳食调查来确定膳食锌缺乏。
平均 SZC（87.2 ± 16.7 μg/dL）和膳食锌摄入量（DRI 的 97 ± 26.9%）正常。17 例 CF 患者中有 3 例（17.6%）出现低锌血症，4 例（23.5%）出现膳食锌缺乏。没有膳食锌缺乏的患者出现低锌血症。SZC 与 BMI 年龄 Z 评分（ = 0.048）和体重身高 Z 评分（ = 0.012）呈正相关，膳食锌摄入量与能量摄入量（EI， = 0.036）和体重身高 Z 评分呈正相关（ = 0.029）。
SZC 与营养状况（BMI 和体重身高 Z 评分）相关，而膳食锌摄入量与 EI 和体重身高 Z 评分相关。没有低锌血症的患者出现膳食锌缺乏。这种情况应该引起我们对边缘性锌缺乏的警惕，这可能解释了为什么两组之间没有重叠病例。我们建议，本研究中约有 41%的病例可能存在锌缺乏风险，可考虑进行锌补充。
Zotero 插件
