Orson Frank M, Kinsey Berma M, Singh Rana A K, Wu Yan, Gardner Tracie, Kosten Thomas R
Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA.
Curr Psychiatry Rep. 2007 Oct;9(5):381-7. doi: 10.1007/s11920-007-0049-z.
Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine.
传统的药物滥用治疗方法仅取得了有限的成功。因此，包括通过接种疫苗来阻断可卡因、尼古丁、甲基苯丙胺和苯环己哌啶等药物作用在内的新方法正在研发中。尽管人们已经提出了一些关于抗药物疫苗作用的可能原理，但最直接和直观的机制可能是血液中的抗体与药物结合，从而阻止药物进入中枢神经系统或降低其进入速率。本综述介绍了影响疫苗诱导药物药效学的理论参数，以及尼古丁、可卡因、甲基苯丙胺和苯环己哌啶疫苗的研发现状。
