预防药物滥用的疫苗。
Vaccines against drug abuse.
机构信息
Immunology Allergy & Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Clin Pharmacol Ther. 2012 Jan;91(1):60-70. doi: 10.1038/clpt.2011.281. Epub 2011 Nov 30.
Abstract
The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are undergoing clinical trials (for cocaine and nicotine addiction) and two that are still in preclinical development (for methamphetamine and heroin addiction). We also outline the challenges and ethical concerns associated with the development of anti-addiction vaccines and their use as future therapeutics.
摘要
目前可用于治疗药物滥用的药物仅取得了有限的成效。旨在诱导产生阻断药物药理作用的抗体的抗成瘾疫苗，在治疗药物滥用方面具有很大的潜力。我们综述了两种正在进行临床试验（针对可卡因和尼古丁成瘾）和两种仍处于临床前开发阶段（针对冰毒和海洛因成瘾）的疫苗的现状。我们还概述了开发抗成瘾疫苗及其用作未来治疗药物所面临的挑战和伦理问题。
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