College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
Fitoterapia. 2014 Jun;95:229-33. doi: 10.1016/j.fitote.2014.03.012. Epub 2014 Mar 29.
Nerve growth factor (NGF) and analog reagents to promote the neurite outgrowth of nerve cells against the neuron degeneration are expected to be potentially useful for the medical treatment of Alzheimer's disease. In our focus on the discovery of bioactive diterpenes, we investigated the chemical constituents of the plant Croton yanhuii. This investigation led to the isolation and identification of two novel clerodane diterpenes (1 and 2). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) and mass (ESIMS and HR-ESIMS) spectroscopic data analyses. Further biological screenings showed that both of the compounds enhanced NGF-mediated neurite outgrowth from PC12 cells.
神经生长因子（NGF）和类似物试剂可促进神经细胞的轴突生长，防止神经元退化，有望成为治疗老年痴呆症的有效手段。在我们专注于发现具有生物活性的二萜类化合物的过程中，对植物思茅黄果厚壳桂的化学成分进行了研究。这一研究导致了两种新型的 clerodane 二萜（1 和 2）的分离和鉴定。基于广泛的 1D 和 2D NMR（COSY、HMQC、HMBC 和 NOESY）和质谱（ESIMS 和 HR-ESIMS）光谱数据分析，确定了它们的结构。进一步的生物学筛选表明，这两种化合物均能增强 NGF 介导的 PC12 细胞的轴突生长。
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