脂联素对无糖尿病肥胖和非肥胖人群低度白蛋白尿的不同影响。
Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes.
作者信息
Yano Yuichiro, Hoshide Satoshi, Ishikawa Joji, Hashimoto Toru, Eguchi Kazuo, Shimada Kazuyuki, Kario Kazuomi
机构信息
From the Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
出版信息
J Clin Hypertens (Greenwich). 2007 Oct;9(10):775-82. doi: 10.1111/j.1524-6175.2007.07321.x.
The goal of this study was to examine the association between adiponectin and low-grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection in 157 participants. Overall, as anticipated, 24-hour systolic blood pressure and fasting glucose levels were independent determinants of UAE (beta=0.254 and 0.176, respectively, P<.05). In obese persons (body mass index [BMI] >/=25 kg/m(2); n=63), adiponectin value was a significant negative determinant of UAE (beta=-0.256, P<.05) independent of blood pressure and glucose levels, whereas in nonobese participants (n=94) it was not. In an analysis of BMI and the median value of adiponectin (9.9 microg/mL), UAE was found to be significantly higher in obese persons with low adiponectin levels than in obese persons with high adiponectin levels (9.20 vs 5.11 microg/min; P<.05), even after adjustment for age, sex, blood pressure level, and glucose level. There was an inverse association between adiponectin and low-grade albuminuria in obese nondiabetic persons.
本研究的目的是探讨脂联素与非糖尿病患者低度蛋白尿之间的关联，以及肥胖和非肥胖个体之间是否存在差异。通过对157名参与者进行过夜尿液收集来评估尿白蛋白排泄量（UAE）。总体而言，正如预期的那样，24小时收缩压和空腹血糖水平是UAE的独立决定因素（β分别为0.254和0.176，P<0.05）。在肥胖者（体重指数[BMI]≥25kg/m²；n=―63）中，脂联素值是UAE的显著负向决定因素（β=―0.256，P<0.05），独立于血压和血糖水平，而在非肥胖参与者（n=94）中则不是。在对BMI和脂联素中位数（9.9μg/mL）的分析中，发现脂联素水平低的肥胖者的UAE显著高于脂联素水平高的肥胖者（9.20对5.11μg/min；P<0.05），即使在调整年龄、性别、血压水平和血糖水平之后也是如此。在肥胖的非糖尿病患者中，脂联素与低度蛋白尿之间存在负相关。
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