Azevedo Henriete A, Villela-Nogueira Cristiane A, Perez Renata M, Segadas-Soares Jorge A, Takahashi Clarina, Gaburo Nelson, Pessoa Isabel, Coelho Henrique Sérgio M
Hepatology Division, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro - Brazil.
J Nephrol. 2007 Sep-Oct;20(5):609-16.
At present it is not clearly established if hepatitis C virus (HCV)-RNA levels and genotype distribution have any peculiar aspect in HCV-infected end-stage renal disease (ESRD) patients. The aim of this study was to evaluate in HCV-infected ESRD patients, the alanine aminotransferase (ALT) profile, HCV-RNA levels and genotype distribution, comparing them with HCV-infected patients with normal renal function.
A cross-sectional study was performed in 66 hemodialysis patients (group 1) and 264 subjects with normal renal function (group 2). All participants in both groups had detectable HCV-RNA. Mean ALT levels were determined in all subjects as well the viral load and the genotype.
Groups were similar according to gender and age. ALT was normal in 74% patients in group 1 and in 23% in group 2 (p<0.001). The median viral load was 5.3 x 10(5) IU/mL in group 1 and 6.6 x 10(5) IU/mL in group 2 (p=0.23). Genotype 1b was the most prevalent in both groups (56% vs. 57%; p=0.38).
HCV-infected ESRD patients have lower ALT levels, but the viral load and the genotype distribution are similar to those observed in HCV-infected individuals with normal renal function.
目前尚不清楚丙型肝炎病毒（HCV）-RNA水平和基因型分布在丙型肝炎病毒感染的终末期肾病（ESRD）患者中是否有任何特殊情况。本研究的目的是评估丙型肝炎病毒感染的ESRD患者的丙氨酸转氨酶（ALT）水平、HCV-RNA水平和基因型分布，并将其与肾功能正常的丙型肝炎病毒感染患者进行比较。
对66例血液透析患者（第1组）和264例肾功能正常的受试者（第2组）进行了一项横断面研究。两组的所有参与者均检测到HCV-RNA。测定了所有受试者的平均ALT水平以及病毒载量和基因型。
两组在性别和年龄方面相似。第1组74%的患者ALT正常，第2组为23%（p<0.001）。第1组的病毒载量中位数为5.3×10⁵IU/mL，第2组为6.6×10⁵IU/mL（p=0.23）。1b基因型在两组中最为常见（分别为56%和57%；p=0.38）。
丙型肝炎病毒感染的ESRD患者ALT水平较低，但病毒载量和基因型分布与肾功能正常的丙型肝炎病毒感染个体相似。
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