Karadeniz Muammer, Erdogan Mehmet, Berdeli Afig, Tamsel Sadik, Saygili Fusun, Yilmaz Candeger
Division of Internal Disease, Department of Endocrinology and Metabolism, Ege University, Izmir, 35100, Turkey.
Cardiovasc Diabetol. 2007 Oct 5;6:29. doi: 10.1186/1475-2840-6-29.
Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS.
Ninety-five young women with PCOS and 99 healthy control women were included in our study. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin and PROGINS polymorphism genetic study.
In PROGINS polymorphism results; in both control and the patient groups T1/T1 has been detected in high levels. But for genotype (p = 0.178) and allele (p = 0.555) frequencies both of the groups give similar results. Statistically significant difference has been detected on serum FSH levels for T1/T1 genotype according to T2/T2 genotype.
No relation has been detected between the inflammatory and oxidative stress factors, and PROGINS polymorphism alleles. This may be because the PCOS patients are young and their BMI means are normal and their CIMT and oxidative stress markers are like healthy women.
据报道，患有多囊卵巢综合征（PCOS）的女性患多种妇科肿瘤的风险增加，包括子宫内膜癌、乳腺癌和卵巢癌。关于孕激素受体多态性的基因变异与卵巢癌和乳腺癌风险之间可能存在的关联的研究主要集中在一种名为PROGINS的变异体上。
我们的研究纳入了95名患有PCOS的年轻女性和99名健康对照女性。所有受试者均接受静脉采血，以进行完整的激素测定、血脂分析、血糖、胰岛素和PROGINS多态性基因研究。
在PROGINS多态性结果中，在对照组和患者组中均检测到高水平的T1/T1。但两组的基因型（p = 0.178）和等位基因（p = 0.555）频率给出了相似的结果。根据T2/T2基因型，在T1/T1基因型的血清促卵泡激素（FSH）水平上检测到统计学上的显著差异。
未检测到炎症和氧化应激因素与PROGINS多态性等位基因之间的关系。这可能是因为PCOS患者较为年轻，其体重指数（BMI）均值正常，且其颈动脉内膜中层厚度（CIMT）和氧化应激标志物与健康女性相似。
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