Ciancia Marina, Quintana Irene, Vizcargüénaga María Isabel, Kasulin Luciana, de Dios Agustina, Estevez José Manuel, Cerezo Alberto Saúl
Cátedra de Química Orgánica, Departamento de Biología Aplicada y Alimentos (CIHIDECAR-CONICET), Facultad de Agronomía, Universidad de Buenos Aires, Avenue San Martín 4453, C1417DSE Buenos Aires, Argentina.
Int J Biol Macromol. 2007 Dec 1;41(5):641-9. doi: 10.1016/j.ijbiomac.2007.08.007. Epub 2007 Aug 31.
Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), alpha(1-->4)-D-glucans and beta(1-->4)-D-mannans. The former polysaccharides are composed by 3-linked beta-D-galactopyranose and beta-L-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content.
脆弱刚毛藻和蠕虫刚毛藻生物合成水溶性硫酸化阿拉伯聚糖和半乳聚糖（和/或硫酸化阿拉伯半乳聚糖）、α(1→4)-D-葡聚糖和β(1→4)-D-甘露聚糖。前者的多糖由3-连接的β-D-吡喃半乳糖和β-L-吡喃阿拉伯糖残基组成，它们高度硫酸化并被丙酮酸缩酮取代。对于这两种海藻来说，它们具有相同的主要结构单元，但比例不同。两种海藻的所有室温水提取物都显示出双重止血作用：它们阻止凝血，但诱导血小板聚集。多糖中硫酸盐含量较高的样品中的抗凝活性和血小板聚集更高，主要是来自蠕虫刚毛藻的样品，其硫酸化程度和阿拉伯糖含量更高。
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