Buchman Aron S, Wilson Robert S, Boyle Patricia A, Bienias Julia L, Bennett David A
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Neuroepidemiology. 2007;29(1-2):66-73. doi: 10.1159/000109498. Epub 2007 Oct 8.
Decline in strength is common in older persons but little data are available about its association with Alzheimer's disease (AD). We studied the association of level of and rate of change in strength in 877 older persons without dementia at baseline and risk of AD. In a proportional hazards model adjusted for age, sex and education, each 1-lb decrease in grip strength at baseline was associated with about a 1.5% increase in the risk of AD (HR, 0.986; 95% CI, 0.973-0.998). These results persisted even after excluding persons who developed AD in the first 5 years of follow-up. In a subsequent model examining the association of the annual rate of change in grip strength with incident AD, each 1-lb annual decline in grip strength was associated with about a 9% increase in the risk of AD (HR, 0.915; 95% CI, 0.884-0.948). Results were similar after controlling for level and rate of change in body mass index, parkinsonian signs, physical and cognitive activity, depressive symptoms, vascular diseases and risk factors, social networks and early-life socioeconomic status. Declining strength in old age is associated with an increased risk of AD.
力量下降在老年人中很常见，但关于其与阿尔茨海默病（AD）关联的数据却很少。我们研究了877名基线时无痴呆且有患AD风险的老年人的力量水平及其变化率之间的关联。在一个根据年龄、性别和教育程度进行调整的比例风险模型中，基线时握力每下降1磅，患AD的风险约增加1.5%（风险比[HR]，0.986；95%置信区间[CI]，0.973 - 0.998）。即使排除在随访的前5年中患AD的人，这些结果仍然成立。在随后一个研究握力年变化率与AD发病关联的模型中，握力每年下降1磅，患AD的风险约增加9%（HR，0.915；95% CI，0.884 - 0.948）。在控制了体重指数的水平和变化率、帕金森病体征、身体和认知活动、抑郁症状、血管疾病及风险因素、社交网络和早年社会经济地位后，结果相似。老年时力量下降与患AD的风险增加有关。
