探究马兜铃烯合酶与12,13-二氟法尼基二磷酸的反应机制。
Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate.
作者信息
Yu Fanglei, Miller David J, Allemann Rudolf K
机构信息
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, UK CF10 3AT.
出版信息
Chem Commun (Camb). 2007 Oct 28(40):4155-7. doi: 10.1039/b709562g. Epub 2007 Aug 6.
DOI:10.1039/b709562g
PMID:17925960
Abstract
12,13-Difluorofarnesyl diphosphate, prepared using Suzuki-Miyaura chemistry, is a potent inhibitor of aristolochene synthase (AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction.
摘要
采用铃木-宫浦化学法制备的12,13-二氟法尼基二磷酸是马兜铃烯合酶（AS）的有效抑制剂，这表明在AS催化过程中的初始环化反应以协同反应方式生成吉马烯阳离子。
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