二磷酸激活中aristolochene 合酶的作用。

The role of aristolochene synthase in diphosphate activation.

机构信息

School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK.

出版信息

Chem Commun (Camb). 2012 Mar 28;48(26):3230-2. doi: 10.1039/c2cc17588f. Epub 2012 Feb 20.

Abstract

Analysis of the role of amino acids involved in diphosphate binding in the Michaelis complex of aristolochene synthase from P. roqueforti (PR-AS) reveals mechanistic details about leaving group (PPi) activation and the nature of the active site acid.

摘要

分析参与二磷酸结合的氨基酸在罗奇福氏曲霉（PR-AS）的贝壳杉烯合酶的迈克尔利斯复合物中的作用，揭示了关于离去基团（PPi）活化和活性位点酸性质的机制细节。