Mark M H, Sage J I, Dickson D W, Heikkila R E, Manzino L, Schwarz K O, Duvoisin R C
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Neurology. 1994 Aug;44(8):1432-6. doi: 10.1212/wnl.44.8.1432.
We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathologic changes of Parkinson's disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.
我们报告了一名患有Meige综合征（节段性颅肌张力障碍）的患者，其在死后检查中出现了帕金森病的神经病理学改变。神经病理学检查显示，在脑干的色素核（黑质、蓝斑）、Meynert基底核和疑核中存在典型和非典型路易小体。对死后脑组织的神经化学分析表明，黑质、纹状体和伏隔核中的多巴胺周转率降低。我们提出，部分Meige综合征病例可能属于路易体病的范畴。
