Aberdein D, Munday J S, Dyer C B, Knight C G, French A F, Gibson I R
Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand.
N Z Vet J. 2007 Oct;55(5):203-7. doi: 10.1080/00480169.2007.36769.
To compare the histology and immunohistochemistry of vaccination-site sarcomas (VSSs) with non-vaccination-site sarcomas (NVSSs) in cats in New Zealand. To determine whether VSSs in cats in New Zealand have similar histological and immunohistochemical features to those previously described in feline vaccine-associated sarcomas (VASs) in North American studies.
A retrospective survey of skin biopsies submitted between 2004 and 2006 was performed to identify cutaneous sarcomas from both vaccination and non-vaccination sites in cats. Vaccination sites included the interscapular, shoulder, or dorsal or lateral cervical and thoracic regions. All sarcomas were examined histologically, and smooth muscle actin and desmin were assessed immunohistochemically. Features previously described in VASs were assessed and compared.
Sarcomas from 34 cats were identified, 10 of which occurred at vaccination sites. Compared with NVSSs, VSSs were more likely to be located in the hypodermis and have greater cellular pleomorphism, higher mitotic rates, more frequent peripheral lymphocytic aggregates and multinucleated giant cells. VSSs were also more likely than NVSSs to show partial myofibroblastic differentiation, demonstrable using immunohistochemistry. The histological and immunohistochemical features of VSSs in cats in New Zealand are consistent with those previously described in VASs in cats in North America.
The results of this study suggest that VASs occur in cats in New Zealand.
The occurrence of VASs in cats in New Zealand would provide further support for restriction of the vaccination of cats to the minimum necessary to protect health, and adoption of the New Zealand Veterinary Association guidelines on vaccination.
比较新西兰猫接种疫苗部位肉瘤（VSS）与非接种疫苗部位肉瘤（NVSS）的组织学和免疫组化特征。确定新西兰猫的VSS是否具有与北美研究中先前描述的猫疫苗相关肉瘤（VAS）相似的组织学和免疫组化特征。
对2004年至2006年间提交的皮肤活检样本进行回顾性调查，以识别猫接种疫苗部位和非接种疫苗部位的皮肤肉瘤。接种疫苗部位包括肩胛间、肩部或颈胸背侧或外侧区域。对所有肉瘤进行组织学检查，并通过免疫组化评估平滑肌肌动蛋白和结蛋白。评估并比较先前在VAS中描述的特征。
共识别出34只猫的肉瘤，其中10只发生在接种疫苗部位。与NVSS相比，VSS更有可能位于皮下，具有更大的细胞多形性、更高的有丝分裂率、更频繁的外周淋巴细胞聚集和多核巨细胞。VSS也比NVSS更有可能表现出部分肌成纤维细胞分化，这可通过免疫组化证实。新西兰猫VSS的组织学和免疫组化特征与北美猫VAS中先前描述的特征一致。
本研究结果表明新西兰猫中存在VAS。
新西兰猫中VAS的出现将为将猫的疫苗接种限制在保护健康所需的最低限度，并采用新西兰兽医协会的疫苗接种指南提供进一步支持。
