Xie Yuanfang, Hu Gang, Sato Daisuke, Weiss James N, Garfinkel Alan, Qu Zhilin
Department of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Phys Rev Lett. 2007 Sep 14;99(11):118101. doi: 10.1103/PhysRevLett.99.118101. Epub 2007 Sep 12.
Ventricular fibrillation is a lethal condition caused by multiple chaotically wandering electrical wavelets in the heart, reentering their own and each other's territories. The development of effective therapies requires a detailed understanding of how these reentrant waves are initiated. In this Letter, we demonstrate a novel mechanism for inducing reentry, in which chaos synchronization causes large-scale heterogeneities of refractoriness transverse to the direction of propagation. These regions of increased refractoriness create localized conduction block, which induces spiral wave reentry.
心室颤动是一种由心脏中多个混乱游走的电小波引起的致命状况,这些电小波重新进入它们自身以及彼此的区域。有效治疗方法的开发需要详细了解这些折返波是如何产生的。在本信函中,我们展示了一种诱导折返的新机制,其中混沌同步导致在传播方向横向的不应期出现大规模异质性。这些不应期增加的区域产生局部传导阻滞,从而诱导螺旋波折返。