Robaday S, Kerleau J-M, Tapon E, Levesque H, Marie I
Département de médecine interne, CHU de Rouen, 76031 Rouen cedex, France.
Rev Med Interne. 2008 Mar;29(3):224-7. doi: 10.1016/j.revmed.2007.08.018. Epub 2007 Sep 21.
Typhlitis is a rare condition, characterized by necrotizing inflammation of the colon. It occurs mainly in neutropenic patients receiving chemotherapy for leukemia.
We report the case of a 64-year-old woman with T-cell lymphocytic leukaemia, who exhibited asymptomatic reactivation of cytomegalovirus infection and developed subsequently typhlitis.
The pathological mechanisms of typhlitis remain unclear in neutropenic patients. The role of cytotoxic drugs as well as both bacterial overgrowth and translocation has been postulated. In our patient, asymptomatic reactivation of cytomegalovirus infection may have increased chemotherapeutic-agents-digestive toxicity.
盲肠炎是一种罕见病症，其特征为结肠的坏死性炎症。它主要发生在接受白血病化疗的中性粒细胞减少患者中。
我们报告了一例64岁患有T细胞淋巴细胞白血病的女性病例，该患者出现了巨细胞病毒感染的无症状再激活，随后发展为盲肠炎。
中性粒细胞减少患者中盲肠炎的病理机制仍不清楚。细胞毒性药物以及细菌过度生长和移位的作用已被提出。在我们的患者中，巨细胞病毒感染的无症状再激活可能增加了化疗药物的消化毒性。
