Hansen H C, Spillum A
Dumex Ltd, Copenhagen, Denmark.
Acta Pharm Nord. 1991;3(3):131-6.
The loss of nitroglycerin (GTN) during passage through a polyvinyl chloride (PVC) or polyethylene (PE) infusion set was investigated. The GTN concentration had no influence on the GTN loss in the PVC set. The study confirmed reports in the literature that the greatest loss of GTN occurs at the slowest rate of infusion. Interestingly, the lowest concentration of GTN is seen when the volume equivalent to the capacity of the infusion set has passed through the set. When we simulated the procedure recommended by the health authorities in Norway and Sweden, we observed a loss of up to 70% during infusion through the PVC set in the first 30 minutes, which decreased to 30% over the next seven hours. The loss from the PE set did not exceed 15% over eight hours.
研究了硝酸甘油（GTN）在通过聚氯乙烯（PVC）或聚乙烯（PE）输液器时的损失情况。GTN浓度对PVC输液器中GTN的损失没有影响。该研究证实了文献中的报道，即GTN损失最大时输液速度最慢。有趣的是，当相当于输液器容量的液体通过输液器时，GTN的浓度最低。当我们模拟挪威和瑞典卫生当局推荐的程序时，我们观察到在前30分钟通过PVC输液器输液时损失高达70%，在接下来的7小时内降至30%。PE输液器在8小时内的损失不超过15%。
