Hibbert Clare L, Piedra Pedro A, McLaurin Kimmie K, Vesikari Timo, Mauskopf Josephine, Mahadevia Parthiv J
RTI Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, United Kingdom.
Vaccine. 2007 Nov 19;25(47):8010-20. doi: 10.1016/j.vaccine.2007.09.018. Epub 2007 Sep 25.
Vaccinating children at day-care may be a cost-effective approach for improving influenza immunization rates in this high-risk group. This study uses influenza attack-rate data from a randomized, blinded, placebo-controlled clinical trial of live-attenuated influenza vaccine, trivalent in day-care centres from two consecutive influenza seasons, one with a moderate attack rate (H1N1 dominant) and one with a high attack rate (H3N2 dominant). Costs were measured in US dollars. In the moderate attack-rate season (vaccinated, 2.2%; placebo, 13.4%), vaccination saved US$ 5.47 per child in societal costs. In the high attack-rate season (vaccinated, 4.7%; placebo, 32.1%), vaccination led to a societal costs savings of US$ 144.44 per child.
在日托中心为儿童接种疫苗可能是提高这一高危群体流感疫苗接种率的一种具有成本效益的方法。本研究使用了来自一项随机、双盲、安慰剂对照临床试验的流感发病率数据，该试验针对两个连续流感季节在日托中心使用的三价减毒活流感疫苗，其中一个季节流感发病率中等（以H1N1为主），另一个季节发病率高（以H3N2为主）。成本以美元计量。在发病率中等的季节（接种疫苗组为2.2%，安慰剂组为13.4%），接种疫苗使每名儿童的社会成本节省了5.47美元。在发病率高的季节（接种疫苗组为4.7%，安慰剂组为32.1%），接种疫苗使每名儿童的社会成本节省了144.44美元。
