青少年起病的边缘型人格障碍的神经生物学基础
The Neurobiological Basis of Adolescent-onset Borderline Personality Disorder.
作者信息
Goodman Marianne, Mascitelli Kathryn, Triebwasser Joseph
机构信息
James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA ; Mount Sinai School of Medicine, New York, New York, USA.
出版信息
J Can Acad Child Adolesc Psychiatry. 2013 Aug;22(3):212-9.
Abstract
OBJECTIVE
Over the past two decades, neurobiological studies in adult onset borderline personality disorder have made important strides, but inquiry into adolescent-onset BPD is still in its infancy and our understanding of the neurobiology of adolescent BPD remains highly tentative.
METHODS
This paper highlights recent findings in genetics, neuroendocrinology and neuroimaging for adult and adolescent-onset BPD.
RESULTS
Neurobiological studies of adolescent-onset BPD to date have focused mainly on volumetric studies of various brain regions and measurements of HPA axis components, with comparatively few publications on brain functioning.
CONCLUSION
Such information is essential to developing more effective screening, treatment and preventive strategies.
摘要
目的
在过去二十年中，成人起病的边缘型人格障碍的神经生物学研究取得了重要进展，但对青少年起病的边缘型人格障碍的研究仍处于起步阶段，我们对青少年边缘型人格障碍神经生物学的理解仍然非常初步。
方法
本文重点介绍了成人和青少年起病的边缘型人格障碍在遗传学、神经内分泌学和神经影像学方面的最新研究结果。
结果
迄今为止，青少年起病的边缘型人格障碍的神经生物学研究主要集中在对各个脑区的体积研究和下丘脑-垂体-肾上腺（HPA）轴成分的测量上，关于脑功能的出版物相对较少。
结论
这些信息对于制定更有效的筛查、治疗和预防策略至关重要。
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