为什么是癌症和炎症？
Why cancer and inflammation?
作者信息
Rakoff-Nahoum Seth
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
Yale J Biol Med. 2006 Dec;79(3-4):123-30.
Central to the development of cancer are genetic changes that endow these "cancer cells" with many of the hallmarks of cancer, such as self-sufficient growth and resistance to anti-growth and pro-death signals. However, while the genetic changes that occur within cancer cells themselves, such as activated oncogenes or dysfunctional tumor suppressors, are responsible for many aspects of cancer development, they are not sufficient. Tumor promotion and progression are dependent on ancillary processes provided by cells of the tumor environment but that are not necessarily cancerous themselves. Inflammation has long been associated with the development of cancer. This review will discuss the reflexive relationship between cancer and inflammation with particular focus on how considering the role of inflammation in physiologic processes such as the maintenance of tissue homeostasis and repair may provide a logical framework for understanding the connection between the inflammatory response and cancer.
癌症发展的核心是基因变化，这些变化赋予这些“癌细胞”许多癌症特征，比如生长自主以及对抑制生长和促死亡信号的抗性。然而，虽然癌细胞自身发生的基因变化，如激活的癌基因或功能失调的肿瘤抑制基因，是癌症发展诸多方面的原因，但这些还不够。肿瘤的促进和进展依赖于肿瘤环境中的细胞所提供的辅助过程，而这些细胞本身不一定是癌细胞。炎症长期以来一直与癌症的发展有关。本综述将讨论癌症与炎症之间的相互关系，特别关注考虑炎症在诸如维持组织稳态和修复等生理过程中的作用如何为理解炎症反应与癌症之间的联系提供一个合理的框架。
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