Porta Chiara, Larghi Paola, Rimoldi Monica, Totaro Maria Grazia, Allavena Paola, Mantovani Alberto, Sica Antonio
DISCAFF, University of Piemonte Orientale A. Avogadro, Novara, Italy.
Immunobiology. 2009;214(9-10):761-77. doi: 10.1016/j.imbio.2009.06.014. Epub 2009 Jul 17.
Several experimental and epidemiological evidence indicate that, irrespective of the trigger for the development (chronic infection/inflammation or genetic alteration), a "smouldering" inflammation is associated with the most of, if not all, tumours and supports their progression. Several evidence have highlighted that tumours promote a constant influx of myelomonocytic cells that express inflammatory mediators supporting pro-tumoral functions. Myelomonocytic cells are key orchestrators of cancer-related inflammation associated with proliferation and survival of malignant cells, subversion of adaptive immune response, angiogenesis, stroma remodelling and metastasis formation. Although the connection between inflammation and cancer is unequivocal the mechanistic basis of such association are largely unknown. Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed.
多项实验和流行病学证据表明，无论肿瘤发生的触发因素是慢性感染/炎症还是基因改变，“隐匿性”炎症都与大多数（即便不是全部）肿瘤相关，并促进其进展。多项证据强调，肿瘤促使表达支持肿瘤功能的炎症介质的骨髓单核细胞持续流入。骨髓单核细胞是与癌细胞增殖和存活、适应性免疫反应颠覆、血管生成、基质重塑及转移形成相关的癌症炎症的关键协调者。尽管炎症与癌症之间的联系确凿无疑，但这种关联的机制基础在很大程度上仍不清楚。本文将讨论在理解癌症相关炎症所涉及的细胞和分子途径方面的最新进展，以及它们作为诊断、预后和治疗靶点的潜在相关性。
