Department of Health Sciences, College of Applied Studies and Community Service, King Saud University, KSA- 4545, Riyadh 11451, Saudi Arabia.
Department of Clinical Nutrition, College of Applied Health Sciences in Ar Rass, Qassim University, Ar Rass 51921, Saudi Arabia.
Molecules. 2022 Dec 13;27(24):8864. doi: 10.3390/molecules27248864.
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show significant anti-inflammatory, anticancer and antioxidant properties. Kaempferol (Kmp) is a well-studied compound and exhibits remarkable anticancer and antioxidant potential. Kmp can regulate various cancer-related processes and activities such as cell cycle, oxidative stress, apoptosis, proliferation, metastasis, and angiogenesis. The anti-cancer properties of Kmp primarily occur via modulation of apoptosis, MAPK/ERK1/2, P13K/Akt/mTOR, vascular endothelial growth factor (VEGF) signalling pathways. The anti-cancer property of Kmp has been recognized in several in-vivo and in-vitro studies which also includes numerous cell lines and animal models. This flavonoid possesses toxic activities against only cancer cells and have restricted toxicity on healthy cells. In this review, we present extensive research investigations about the therapeutic potential of Kmp in the management of different types of cancers. The anti-cancer properties of Kmp are discussed by concentration on its capability to target molecular-signalling pathway such as VEGF, STAT, p53, NF-κB and PI3K-AKT signalling pathways. The anti-cancer property of Kmf has gained a lot of attention, but the accurate action mechanism remains unclear. However, this natural compound has a great pharmacological capability and is now considered to be an alternative cancer treatment.
植物衍生类黄酮被认为是天然无毒的化学预防剂，近年来在癌症治疗方面得到了广泛研究。大多数类黄酮化合物都具有显著的抗炎、抗癌和抗氧化特性。山奈酚（Kmp）是一种研究较多的化合物，具有显著的抗癌和抗氧化潜力。Kmp 可以调节各种与癌症相关的过程和活动，如细胞周期、氧化应激、细胞凋亡、增殖、转移和血管生成。Kmp 的抗癌特性主要通过调节细胞凋亡、MAPK/ERK1/2、PI3K/Akt/mTOR、血管内皮生长因子（VEGF）信号通路来实现。Kmp 的抗癌特性已在几项体内和体外研究中得到证实，其中包括许多细胞系和动物模型。这种类黄酮对癌细胞具有毒性作用，而对健康细胞的毒性有限。在这篇综述中，我们介绍了关于 Kmp 在管理不同类型癌症方面的治疗潜力的广泛研究调查。通过集中讨论 Kmp 靶向分子信号通路的能力，如 VEGF、STAT、p53、NF-κB 和 PI3K-AKT 信号通路，讨论了 Kmp 的抗癌特性。Kmp 的抗癌特性引起了广泛关注，但确切的作用机制仍不清楚。然而，这种天然化合物具有很强的药理学能力，现在被认为是一种癌症治疗的替代方法。
