Elahi Behzad, Nikfar Shekoufeh, Derakhshani Saeed, Vafaie Mohammad, Abdollahi Mohammad
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dig Dis Sci. 2008 May;53(5):1278-84. doi: 10.1007/s10620-007-0006-z. Epub 2007 Oct 17.
The objective of this study was to evaluate and collect current evidence on the effect of probiotics in preventing pouchitis after restorative ileal pouch anal anastomosis (IPAA). The Pubmed, Medline, EMbase, CINAHL, Web of Science, and Scopus bibliographic, and Google Scholar databases were searched between 1966 and May 2007, and relevant controlled clinical trials were extracted, reviewed, and validated according to the study protocol. The outcome of interest was for pouchitis defined by a pouchitis disease activity index (PDAI) > or =7. Five randomized, placebo-controlled clinical trials were included in the meta-analysis. Pooling of the results from these trials yielded an odds ratio (OR) of 0.04 with a 95% CI of 0.01-0.14 (P < 0.0001) in the treatment group in comparison with the placebo group. In conclusion, the benefit of probiotics in the management of pouchitis after IPAA operation was confirmed by the meta-analysis.
本研究的目的是评估并收集有关益生菌在预防回肠储袋肛管吻合术（IPAA）后袋炎方面作用的现有证据。检索了1966年至2007年5月期间的PubMed、Medline、EMbase、CINAHL、科学网、Scopus书目数据库以及谷歌学术数据库，并根据研究方案提取、审查和验证了相关对照临床试验。感兴趣的结果是袋炎疾病活动指数（PDAI）≥7所定义的袋炎。荟萃分析纳入了五项随机、安慰剂对照临床试验。与安慰剂组相比，这些试验结果的合并得出治疗组的优势比（OR）为0.04，95%置信区间为0.01 - 0.14（P < 0.0001）。总之，荟萃分析证实了益生菌在IPAA术后袋炎管理中的益处。
