紫外线B联合焦油疗法对银屑病患者血清白细胞介素-2受体水平的影响。

Effect of UVB plus tar therapy on serum levels of interleukin-2 receptors in patients with psoriasis.

作者信息

Betti R, Rosti A, Lodi A, Bencini P L, Paparelli S, Gazzola G B, Cori P, Moroni G A, Crosti C

机构信息

Dermatology Clinic, University of Milan, Italy.

出版信息

Clin Exp Dermatol. 1991 Sep;16(5):364-6. doi: 10.1111/j.1365-2230.1991.tb00402.x.

DOI:10.1111/j.1365-2230.1991.tb00402.x

PMID:1794191

Abstract

Baseline serum levels of interleukin-2 receptor (IL2R) were measured in 65 patients with active psoriasis. IL2R levels in psoriatic patients were significantly higher than in healthy controls (582.4 +/- 289.23 u/ml vs. 369.64 +/- 111.10 u/ml; P less than 0.05), but did not differ statistically from values found in an atopic dermatitis control group (619.88 +/- 254.27 u/ml). Sex, age and severity of the disease do not affect levels of IL2R. The same IL2R levels were measured in 26 psoriatic patients receiving UVB plus tar therapy. This therapy, continued until clinical remission, lowered IL2R levels to values comparable to controls. This decrease may be due to an immunosuppressive effect of therapy.

摘要

对65例活动性银屑病患者测定了白细胞介素-2受体（IL2R）的基线血清水平。银屑病患者的IL2R水平显著高于健康对照者（582.4±289.23 U/ml对369.64±111.10 U/ml；P<0.05），但与特应性皮炎对照组的值无统计学差异（619.88±254.27 U/ml）。疾病的性别、年龄和严重程度不影响IL2R水平。对26例接受UVB加焦油治疗的银屑病患者测定了相同的IL2R水平。该治疗持续至临床缓解，将IL2R水平降至与对照组相当的值。这种下降可能是由于治疗的免疫抑制作用。