18F-FDG PET/CT对特发性颈部肌张力障碍中肌张力障碍肌肉的定位
Localization of dystonic muscles with 18F-FDG PET/CT in idiopathic cervical dystonia.
作者信息
Sung Duk Hyun, Choi Joon Young, Kim Du-Hwan, Kim Eun-Sang, Son Young-Ik, Cho Young-Seok, Lee Su Jin, Lee Kyung-Han, Kim Byung-Tae
机构信息
Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
J Nucl Med. 2007 Nov;48(11):1790-5. doi: 10.2967/jnumed.107.044024. Epub 2007 Oct 17.
UNLABELLED
The purpose of this study was to investigate whether (18)F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles.
METHODS
Six patients with ICD underwent (18)F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased (18)F-FDG uptake.
RESULTS
Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during (18)F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/CT and who were clinically monitored.
CONCLUSION
(18)F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD.
未标注
本研究的目的是通过比较肉毒杆菌毒素（BT）注射到代谢亢进肌肉前后的疾病严重程度，探讨（18）F-FDG PET/CT是否有助于特发性颈部肌张力障碍（ICD）患者定位肌张力障碍的颈部肌肉。
方法
6例ICD患者接受了（18）F-FDG PET/CT检查。适合BT注射治疗的肌张力障碍肌肉定义为显示（18）F-FDG摄取弥漫性增加的肌肉。
结果
所有6例患者均发现代谢亢进的颈部肌肉。在2例在（18）F-FDG摄取期间仰卧位和坐位均接受PET/CT检查的患者中，仅当患者处于坐位且头颈部处于所采用的异常不自主姿势时，PET/CT才观察到异常代谢亢进的肌肉。4例接受PET/CT引导下BT注射治疗并接受临床监测的患者症状明显改善。
结论
（18）F-FDG PET/CT可能有助于识别ICD患者中用于BT治疗的肌张力障碍颈部肌肉。
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